منابع مشابه
The left-handed double helical nucleic acids.
The conversion of right-handed dsDNA and dsRNA to the left-handed Z-conformation involves a reorganization of the nucleotides relative to each other. This conversion can be facilitated by the tight binding of a Z-conformation-specific protein domain from the editing enzyme dsRNA adenosine deaminase. This may influence the modification of both pre-mRNAs as well as some replicating RNA viruses.
متن کاملConstruction of right-handed-, left-handed-, and racemic helical coordination polymers. Enantioselective recognition using chiral helical crystals.
Infinite square-tubular helices, [CuCl2(L)(S)] (L = bis(4-pyridyl)methylvinylsilane; S = Me2SO, HCONMe2), were constructed. This helical system affords three kinds of P, M crystals in Me2SO, and racemic crystals in HCONMe2. The cyclic voltammogram (CV) technique using the M-crystals is an effective tool for discerning the chirality of proline.
متن کاملBase extrusion is found at helical junctions between right- and left-handed forms of DNA and RNA
Base extrusion is a major structural feature at the junction between B- and Z-DNA (the B-Z junction) where a base pair is broken, and the two bases are extruded from the double helix. Despite the demonstration of base extrusion at the B-Z junction, it is not clear whether a similar base extrusion occurs at other types of junctions involving the left-handed Z conformation. Here, we investigate s...
متن کاملStructure of a left-handed DNA G-quadruplex.
Aside from the well-known double helix, DNA can also adopt an alternative four-stranded structure known as G-quadruplex. Implications of such a structure in cellular processes, as well as its therapeutic and diagnostic applications, have been reported. The G-quadruplex structure is highly polymorphic, but so far, only right-handed helical forms have been observed. Here we present the NMR soluti...
متن کاملThermodynamics of left-handed
The thermodynamics of rightand left-handed helix formation by poly[d(G-C)].poly[d(G-C)] and by poly(dG-mSdC).poly(dG-msdC) were measured spectrophotometrically and calorimetrically. From the spectrophotometric measurements the thermal stabilities of the alternative helical conformations were evaluated as a function of counterion concentration. From the calorimetric measurements the enthalpies o...
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ژورنال
عنوان ژورنال: Open Journal of Molecular and Integrative Physiology
سال: 2014
ISSN: 2162-2159,2162-2167
DOI: 10.4236/ojmip.2014.42003